Sear J W, Prys-Roberts C, Dye A
Br J Anaesth. 1983 Jul;55(7):603-9. doi: 10.1093/bja/55.7.603.
Three groups of patients received Althesin, minaxolone or di-isopropyl phenol to supplement 67% nitrous oxide in oxygen. A fourth group receiving halothane to supplement nitrous oxide in oxygen acted as a control. Hepatic function tests were measured before operation and on days 1, 3, 5 and 7 after major vascular reconstructive surgery. There were significant increases to a mean value above the upper limit of normal in aspartate amino-transferase activity by day 3 in all groups. Total lactic dehydrogenase activity increased in the patients receiving Althesin, minaxolone and halothane. No change was seen in the alkaline phosphatase in any of the study groups. Gamma glutamyl transpeptidase increased in all groups, but the mean value at day 7 was not greater than the upper limit of normal. The mean activity of ornithine carbamoyl transpeptidase showed no change in any group throughout the study period. Two of the patients receiving minaxolone suffered cholestatic jaundice during the first month. These results suggest that anaesthesia with Althesin or di-isopropyl phenol results in enzyme changes similar to those seen in a comparable group of patients receiving halothane to supplement nitrous oxide in oxygen anaesthesia.
三组患者接受了阿法沙龙、米那索龙或二异丙基酚，以补充67%的氧化亚氮和氧气。第四组接受氟烷以补充氧化亚氮和氧气作为对照。在大血管重建手术前以及术后第1、3、5和7天测量肝功能测试。到第3天，所有组的天冬氨酸氨基转移酶活性均显著升高至高于正常上限的平均值。接受阿法沙龙、米那索龙和氟烷的患者总乳酸脱氢酶活性增加。在任何研究组中，碱性磷酸酶均未见变化。所有组的γ-谷氨酰转肽酶均升高，但第7天的平均值不高于正常上限。在整个研究期间，任何组的鸟氨酸氨基甲酰转移酶平均活性均无变化。两名接受米那索龙的患者在第一个月内出现胆汁淤积性黄疸。这些结果表明，使用阿法沙龙或二异丙基酚麻醉导致的酶变化与在一组接受氟烷补充氧化亚氮和氧气麻醉的类似患者中观察到的变化相似。
