Use of an emulsion of ICI 35868 (propofol) for the induction and maintenance of anaesthesia.

2,6-Diisopropyl phenol in a fat emulsion formulation (propofol) has been used to supplement 67% nitrous oxide in oxygen anaesthesia in 20 patients premedicated with morphine 0.15 mg kg-1 and atropine 0.6 mg, and undergoing body surface surgery. Following an induction dose of propofol 2.5 mg kg-1, the mean maintenance dose was 73.4 micrograms kg-1 min-1. When compared with 10 patients receiving Althesin to supplement nitrous oxide in oxygen in a similar manner, recovery was considerably faster following propofol. The only major side-effect associated with the use of propofol was pain on injection in nine out of 20 patients. When the patients receiving propofol were compared with a second control group (n = 11) in whom anaesthesia was induced with thiopentone 4 mg kg-1 and maintained with 1% halothane and nitrous oxide in oxygen, the former group showed a significant (P less than 0.01) decrease in the plasma cortisol concentration 30 min after the induction of anaesthesia. However, by 3 h after induction, the cortisol concentration in both groups was not significantly different from the baseline (preinduction) value. The mechanism of this decrease is not known. Investigation of the influence of the fat emulsion on blood coagulation and fibrinolysis revealed no differences when compared with patients receiving Althesin.