Kay N H, Uppington J, Sear J W, Allen M C
Br J Anaesth. 1985 Aug;57(8):736-42. doi: 10.1093/bja/57.8.736.
2,6-Diisopropyl phenol in a fat emulsion formulation (propofol) has been used to supplement 67% nitrous oxide in oxygen anaesthesia in 20 patients premedicated with morphine 0.15 mg kg-1 and atropine 0.6 mg, and undergoing body surface surgery. Following an induction dose of propofol 2.5 mg kg-1, the mean maintenance dose was 73.4 micrograms kg-1 min-1. When compared with 10 patients receiving Althesin to supplement nitrous oxide in oxygen in a similar manner, recovery was considerably faster following propofol. The only major side-effect associated with the use of propofol was pain on injection in nine out of 20 patients. When the patients receiving propofol were compared with a second control group (n = 11) in whom anaesthesia was induced with thiopentone 4 mg kg-1 and maintained with 1% halothane and nitrous oxide in oxygen, the former group showed a significant (P less than 0.01) decrease in the plasma cortisol concentration 30 min after the induction of anaesthesia. However, by 3 h after induction, the cortisol concentration in both groups was not significantly different from the baseline (preinduction) value. The mechanism of this decrease is not known. Investigation of the influence of the fat emulsion on blood coagulation and fibrinolysis revealed no differences when compared with patients receiving Althesin.
脂肪乳剂配方中的2,6 - 二异丙基苯酚（丙泊酚）已用于20例预先用0.15mg/kg吗啡和0.6mg阿托品进行术前用药并接受体表手术的患者，作为67%氧化亚氮 - 氧气麻醉的补充。给予2.5mg/kg丙泊酚诱导剂量后，平均维持剂量为73.4μg/kg·min。与10例以类似方式接受阿法沙龙补充氧化亚氮 - 氧气的患者相比，丙泊酚麻醉后恢复明显更快。使用丙泊酚的唯一主要副作用是20例患者中有9例出现注射痛。将接受丙泊酚的患者与第二对照组（n = 11）进行比较，第二对照组用4mg/kg硫喷妥钠诱导麻醉并用1%氟烷和氧化亚氮 - 氧气维持麻醉，前一组在麻醉诱导后30分钟血浆皮质醇浓度显著降低（P < 0.01）。然而，诱导后3小时，两组的皮质醇浓度与基线（诱导前）值无显著差异。这种降低的机制尚不清楚。对脂肪乳剂对凝血和纤溶影响的研究表明，与接受阿法沙龙的患者相比无差异。
