锌、铜和镉在非洲爪蟾（Xenopus laevis）中诱导产生的金属硫蛋白的特性。
Properties of metallothionein induced by zinc, copper and cadmium in the frog, Xenopus laevis.
作者信息
Suzuki K T, Tanaka Y, Kawamura R
出版信息
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1983;75(1):33-7. doi: 10.1016/0742-8413(83)90007-5.
PMID:6135558
Abstract
- Repeated injections of zinc (Zn) and copper (Cu) into the frog Xenopus laevis caused accumulations of the respective metals in the liver and kidney. 2. The accumulated metals in the liver supernatant fractions were present as Zn- and Cu-binding proteins of the same properties as that of metallothionein (MT) induced by cadmium (Cd) injections. 3. The affinity of Zn, Cu and Cd ions to the metal-binding protein was in the decreasing order of Cu, Cd and Zn. 4. The Xenopus MT induced by Cd was unstable and disrupted easily to give two peaks as if the MT consists of two isometallothioneins.
摘要
- 向非洲爪蟾（Xenopus laevis）反复注射锌（Zn）和铜（Cu）会导致这两种金属分别在肝脏和肾脏中蓄积。2. 肝脏上清液组分中蓄积的金属以与注射镉（Cd）诱导产生的金属硫蛋白（MT）性质相同的锌结合蛋白和铜结合蛋白形式存在。3. 锌、铜和镉离子与金属结合蛋白的亲和力顺序为铜＞镉＞锌。4. 镉诱导产生的非洲爪蟾金属硫蛋白不稳定，容易分解为两个峰，就好像该金属硫蛋白由两种异金属硫蛋白组成。
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