• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Histamine receptor blockade (H2) versus inhibition of histamine synthesis in stress ulceration in rats.

作者信息

Bouclier M, Jung M J, Gerhart F

出版信息

Eur J Pharmacol. 1983 May 20;90(1):129-32. doi: 10.1016/0014-2999(83)90224-8.

DOI:10.1016/0014-2999(83)90224-8
PMID:6135617
Abstract

Cold and restraint stress in rats induced gastric mucosa lesions, increased gastric mucosa histidine decarboxylase activity and elevated hypothalamic content. Cimetidine did not modify the biochemical effects induced by stress but partially protected against gastric ulceration. alpha-Fluoromethyl histidine inhibited the increase of histidine decarboxylase activity in the gastric mucosa, inhibited the rise of hypothalamic histamine content and decreased the incidence of gastric lesions to the same extent as did cimetidine.

摘要

相似文献

1
Histamine receptor blockade (H2) versus inhibition of histamine synthesis in stress ulceration in rats.
Eur J Pharmacol. 1983 May 20;90(1):129-32. doi: 10.1016/0014-2999(83)90224-8.
2
Induction of gastric histamine synthesis by H2-receptor antagonists: potentiation of their antisecretory activity by histidine decarboxylase inhibitors.
Agents Actions. 1980 Sep;10(4):302-8. doi: 10.1007/BF01971429.
3
Effect of cimetidine on gastric mucosal histamine and histidine decarboxylase activity in rats.西咪替丁对大鼠胃黏膜组胺及组氨酸脱羧酶活性的影响。
Digestion. 1977 Feb;15(2):121-8. doi: 10.1159/000197993.
4
alpha-Fluoromethyl histidine. Inhibition of histidine decarboxylase in pylorus ligated rat.α-氟甲基组氨酸。对幽门结扎大鼠体内组氨酸脱羧酶的抑制作用。
Biochem Pharmacol. 1983 May 15;32(10):1553-6. doi: 10.1016/0006-2952(83)90326-x.
5
[Effects of the anti-ulcer agents on the amine contents and regulating enzyme activity of gastric mucosa during the healing process of acetic acid induced gastric ulcer in rats].
Nihon Yakurigaku Zasshi. 1990 Jan;95(1):15-20. doi: 10.1254/fpj.95.1_15.
6
Role of histaminergic mechanisms in the regulation of some stress responses in rats.
Pharmacol Biochem Behav. 1991 Aug;39(4):847-50. doi: 10.1016/0091-3057(91)90042-z.
7
Inhibition of histamine biosynthesis and gastric function in the rat: effect on pentagastrin-induced gastric acid secretion.大鼠组胺生物合成及胃功能的抑制：对五肽胃泌素诱导胃酸分泌的影响
Agents Actions. 1983 Apr;13(2-3):241-6. doi: 10.1007/BF01967342.
8
Regulation of histamine synthesis: altered synthesis and level of histamine in the hypothalamus of rats by repeated administration of histamine H1 and H2 receptor antagonists.
Agents Actions. 1980 Apr;10(1 Pt 2):98-100. doi: 10.1007/BF02024186.
9
Histamine synthesis after administration of gastrin and blockade of acid secretion in the rat stomach.胃泌素给药后大鼠胃中组胺的合成及胃酸分泌的阻断
Tokai J Exp Clin Med. 1989 Sep;14(4):309-14.
10
Apomorphine-induced turning behavior in 6-hydroxydopamine lesioned rats is increased by histidine and decreased by histidine decarboxylase, histamine H1 and H2 receptor antagonists, and an H3 receptor agonist.在6-羟基多巴胺损伤的大鼠中，阿扑吗啡诱导的旋转行为可被组氨酸增强，并被组氨酸脱羧酶、组胺H1和H2受体拮抗剂以及H3受体激动剂减弱。
Pharmacol Biochem Behav. 2008 Sep;90(3):325-30. doi: 10.1016/j.pbb.2008.03.010. Epub 2008 Mar 25.

引用本文的文献

1
Bile acid increases expression of the histamine-producing enzyme, histidine decarboxylase, in gastric cells.胆汁酸可增加胃细胞中产生组胺的酶——组氨酸脱羧酶的表达。
World J Gastroenterol. 2014 Jan 7;20(1):175-82. doi: 10.3748/wjg.v20.i1.175.
2
Effect of psychogenic stress on gastrointestinal function.心理性应激对胃肠功能的影响。
J Physiol Biochem. 2000 Sep;56(3):259-74. doi: 10.1007/BF03179794.
3
The regulation of histidine decarboxylase gene expression.组氨酸脱羧酶基因表达的调控。
Yale J Biol Med. 1996 Jan-Feb;69(1):21-33.