α-肾上腺素能受体阻滞剂在高血压治疗中的作用。

The role of alpha-adrenoceptor blockade in the treatment of hypertension.

作者信息

Abrams S M, Turner P

出版信息

J Clin Hosp Pharm. 1983 Jun;8(2):175-81. doi: 10.1111/j.1365-2710.1983.tb01048.x.

DOI:10.1111/j.1365-2710.1983.tb01048.x

Abstract

Early attempts to use alpha-adrenoceptor blockers in the treatment of hypertension were unsuccessful due to a high prevalence of side-effects. Now that the concept of two alpha-adrenoceptors, alpha 1 and alpha 2 has been investigated, specific alpha 1 postsynaptic adrenoceptor blocking drugs have become available to treat hypertension. Their efficacy, tolerance and acceptability are discussed, and indications for their usage suggested.

摘要

早期使用α-肾上腺素能受体阻滞剂治疗高血压的尝试因副作用发生率高而未成功。既然已经对α1和α2这两种α-肾上腺素能受体的概念进行了研究，那么用于治疗高血压的特异性α1突触后肾上腺素能受体阻断药物已经问世。本文讨论了它们的疗效、耐受性和可接受性，并提出了其使用指征。