Roehrs T, Zorick F, Lord N, Koshorek G L, Roth T
J Clin Psychopharmacol. 1983 Jun;3(3):152-6.
The dose range of estazolam for hypnotic effects was studied in seven men and eight women (mean age 30.3 +/- 8.6 years) who complained of insomnia and had polysomnographic evidence of disturbed sleep. Patients slept in the laboratory and were monitored using standard polysomnographic techniques. Four consecutive nights in the laboratory with placebo, which served as baseline and screening nights, were followed by five 2-night drug administration periods separated by 5-day drug washout periods spent at home. Each of the patients received a sequence of four doses (0.25, 0.5, 1.0, and 2.0 mg) of estazolam and placebo administered according to a Latin square design and in a double-blind manner. Estazolam significantly increased total sleep time and reduced time awake during sleep in a dose-dependent manner. Sleep latency parameters were reduced systematically with increasing doses of estazolam, but these effects on sleep latency were not statistically significant. Increasing doses of estazolam had systematic and statistically significant effects on sleep stages. Subjective estimations of sleep were consistent with the polysomnographic findings bur were not statistically significant.
对7名男性和8名女性（平均年龄30.3±8.6岁）进行了研究，这些人主诉失眠且有多导睡眠图显示睡眠紊乱的证据，研究了艾司唑仑催眠作用的剂量范围。患者在实验室睡眠，并使用标准多导睡眠图技术进行监测。在实验室连续4晚服用安慰剂，作为基线和筛查夜，随后是5个为期2晚的药物给药期，期间间隔5天在家进行药物洗脱期。每位患者按照拉丁方设计和双盲方式接受4种剂量（0.25、0.5、1.0和2.0毫克）的艾司唑仑和安慰剂。艾司唑仑以剂量依赖的方式显著增加总睡眠时间并减少睡眠期间的觉醒时间。随着艾司唑仑剂量增加，睡眠潜伏期参数系统性降低，但这些对睡眠潜伏期的影响无统计学意义。艾司唑仑剂量增加对睡眠阶段有系统性且具有统计学意义的影响。睡眠的主观评估与多导睡眠图结果一致，但无统计学意义。
