Morooka S, Tanaka S, Ohya T, Takano T, Ohtani Y, Takeda T, Murao S
Jpn Heart J. 1983 May;24(3):471-80. doi: 10.1536/ihj.24.471.
Three patients with mitral regurgitation (MR) associated with aortitis syndrome are presented. All had multiple lesions of the large sized arteries, calcification of the aorta, mild inflammatory findings, a chronic course, and congestive heart failure. MR was observed by ventriculography in all 3 patients. Case 1 had mitral valve prolapse and secondary systemic hypertension. Case 2 showed mildly thickened mitral valve leaflets and had moderate aortic regurgitation (AR). Case 3 had massive AR. The grade of MR was moderate in Cases 1 and 2, and massive in Case 3. The left ventricle was moderately dilated in Cases 1 and 2 but contracted sufficiently and symmetrically in all 3 patients. Other than the prolapse, no significant mitral valve deformity or left ventricular asynergy was evident by ventriculography. The incidence of MR was 3.1% of 128 patients with aortitis syndrome observed in our clinic. MR may be found in the late stage of aortitis syndrome. It may be caused by a mild valvular lesion related to aortitis syndrome and be exacerbated by increased hemodynamic loads such as those which occur in secondary hypertension and AR.
本文报告了3例与大动脉炎综合征相关的二尖瓣反流（MR）患者。所有患者均有大动脉多发病变、主动脉钙化、轻度炎症表现、病程呈慢性且伴有充血性心力衰竭。所有3例患者经心室造影均观察到MR。病例1有二尖瓣脱垂及继发性系统性高血压。病例2二尖瓣叶轻度增厚，并有中度主动脉瓣反流（AR）。病例3有大量AR。病例1和病例2的MR程度为中度，病例3为大量。病例1和病例2左心室中度扩张，但所有3例患者左心室收缩充分且对称。除脱垂外，心室造影未发现明显的二尖瓣显著畸形或左心室运动失调。在我院门诊观察的128例大动脉炎综合征患者中，MR的发生率为3.1%。MR可能在大动脉炎综合征晚期出现。它可能由与大动脉炎综合征相关的轻度瓣膜病变引起，并因继发性高血压和AR等血流动力学负荷增加而加重。
