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病毒是否会像在犬瘟热脑脊髓炎中那样,在多发性硬化症的葡萄膜中持续存在?

Does virus persist in the uvea in multiple sclerosis, as in canine distemper encephalomyelitis?

作者信息

Summers B A, Greisen H A, Appel M J

出版信息

Lancet. 1983 Aug 13;2(8346):372-5. doi: 10.1016/s0140-6736(83)90346-x.

Abstract

Epidemiological studies suggest that multiple sclerosis (MS) might be triggered by an infectious agent. Uveitis has been observed in a small percentage of MS patients. Dogs with canine distemper encephalomyelitis, another demyelinating disease of the central nervous system, have an anterior uveitis which is usually mild and asymptomatic, and dogs with persistent CNS infection and chronic distemper encephalomyelitis harbour virus persistently in the uvea. These observations in dogs suggest that pathological and virological studies of the uveitis associated with MS would be worth while.

摘要

流行病学研究表明,多发性硬化症(MS)可能由感染因子引发。在一小部分MS患者中观察到了葡萄膜炎。患有犬瘟热脑脊髓炎(另一种中枢神经系统脱髓鞘疾病)的犬类有前葡萄膜炎,通常症状轻微且无症状,而患有持续性中枢神经系统感染和慢性犬瘟热脑脊髓炎的犬类在葡萄膜中持续携带病毒。对犬类的这些观察表明,对与MS相关的葡萄膜炎进行病理学和病毒学研究是值得的。

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