Hefton J M, Madden M R, Finkelstein J L, Shires G T
Lancet. 1983 Aug 20;2(8347):428-30. doi: 10.1016/s0140-6736(83)90392-6.
Epidermal cells from cadaver skin grown in culture into confluent sheets of stratified cells were grafted on to partial thickness burn wounds in three patients. The burn areas covered with these allogeneic cultured epidermal allografts were tangentially excised deep second-degree burns which routinely would have been covered with split-thickness autografts. The burn wounds grafted with cultured allografts healed within three days and remained healthy for the 9 months of observation. Since epidermal cell cultures may be grown continuously, cultured allografts may serve as alternative biological dressings, or grafts, for deep second-degree burn wounds. They produce accelerated healing and an excellent cosmetic result, and they reduce the need for split-thickness autografts.
取自尸体皮肤的表皮细胞在培养中生长成融合的分层细胞片，然后移植到三名患者的部分厚度烧伤创面上。覆盖这些同种异体培养表皮移植片的烧伤区域为切痂的深二度烧伤，常规情况下这些创面会用中厚自体皮覆盖。移植了培养异体皮的烧伤创面在三天内愈合，并且在九个月的观察期内保持健康。由于表皮细胞培养可以持续进行，培养异体皮可作为深二度烧伤创面的替代生物敷料或移植片。它们能加速愈合并产生极佳的美容效果，还能减少对中厚自体皮的需求。
