Madden M R, Finkelstein J L, Staiano-Coico L, Goodwin C W, Shires G T, Nolan E E, Hefton J M
J Trauma. 1986 Nov;26(11):955-62. doi: 10.1097/00005373-198611000-00001.
Twenty-six individuals with second- and third-degree burn wounds have been grafted with cultured allogeneic epidermal cells. These epidermal cell grafts were grown in culture from cadaver skin according to a technique which we have developed. After being grafted with cultured allogeneic epidermal cells, superficial wounds, e.g., donor sites, healed within 7 days, compared to 14 days for mirror image control sites. Deep second-degree burn wounds which were excised before grafting with cultured cells healed in a mean time of 10 days. Deep second-degree burn wounds which were not excised before grafting healed in a mean time of 14 days. The cultured cells produced rapid healing in 11 of the 12 patients with deep second-degree burn wounds. The deep second-degree wounds grafted with cultured allogeneic epidermal cells healed with results which were comparable to the deep second-degree wounds which were autografted. Grafts of cultured allogeneic epidermal cells placed on full-thickness, or third-degree burn, wounds did not grow well.
26名二度和三度烧伤患者接受了培养的同种异体表皮细胞移植。这些表皮细胞移植物是根据我们开发的技术从尸体皮肤在培养中生长而来的。在移植培养的同种异体表皮细胞后，浅表伤口，如供皮区，在7天内愈合，而镜像对照部位则需要14天。在移植培养细胞前切除的深二度烧伤伤口平均在10天内愈合。在移植前未切除的深二度烧伤伤口平均在14天内愈合。培养的细胞使12例深二度烧伤患者中的11例实现了快速愈合。移植培养的同种异体表皮细胞的深二度伤口愈合情况与自体移植的深二度伤口相当。将培养的同种异体表皮细胞移植到全层或三度烧伤伤口上生长不佳。
