Manifold I H, Triger D R, Underwood J C
Lancet. 1983 Aug 20;2(8347):431-3. doi: 10.1016/s0140-6736(83)90393-8.
It is suggested that the increased incidence of hepatocellular carcinoma complicating cirrhosis may be related to the lobular and nodular depletion of liver macrophages. The occurrence of other hepatic tumours can also be related to the anatomical distribution of these macrophages within the liver. These observations are consistent with the hypothesis that the liver macrophage (Kupffer cell) may play an important role in tumour surveillance.
有人认为，肝硬化并发肝细胞癌发病率的增加可能与肝脏巨噬细胞的小叶和结节性耗竭有关。其他肝脏肿瘤的发生也可能与这些巨噬细胞在肝脏内的解剖分布有关。这些观察结果与肝脏巨噬细胞（库普弗细胞）可能在肿瘤监测中起重要作用的假说一致。
