Myslobodsky M, Feldon J, Lerner T
Life Sci. 1983 Jul 25;33(4):317-21. doi: 10.1016/s0024-3205(83)80003-4.
The possibility that Ro 15-1788, a specific benzodiazepine antagonist would reverse the anxiolytic effect of VPA (200 mg/kg) in the Geller-Seifter paradigm was tested, using male albino rats. VPA (200 mg/kg) induced disinhibition which was antagonized by a convulsant benzodiazepine, Ro 5-3663 (1 mg/kg), but not by imidazobenzodiazepine, Ro 15-1788 at doses of 10 mg/kg, or 30 mg/kg. However, Ro 15-1788 (30 mg/kg) did have a short lasting antagonistic effect on VPA when tested in a "condensed" form (see text) of the conflict test. The nature of the anticonflict potency of VPA is discussed.
利用雄性白化大鼠，测试了特异性苯二氮䓬拮抗剂Ro 15 - 1788能否在盖勒-赛弗特范式中逆转丙戊酸（200毫克/千克）的抗焦虑作用。丙戊酸（200毫克/千克）诱导了去抑制作用，该作用被惊厥性苯二氮䓬Ro 5 - 3663（1毫克/千克）拮抗，但10毫克/千克或30毫克/千克剂量的咪唑苯二氮䓬Ro 15 - 1788未产生拮抗作用。然而，当在冲突测试的“浓缩”形式（见正文）中进行测试时，Ro 15 - 1788（30毫克/千克）对丙戊酸确实有短暂的拮抗作用。文中讨论了丙戊酸抗冲突效力的性质。
