哮喘患者吸入特定草花粉抗原的激发试验及三甲噻米哒洛草酰胺的作用
Inhalation challenge with specific grass pollen antigens in asthmatics and the effect of lodoxamide tromethamine.
作者信息
Parrish R W, Davies B H
出版信息
Thorax. 1983 Jun;38(6):458-62. doi: 10.1136/thx.38.6.458.
Abstract
Highly purified species-specific grass pollen antigens were used for inhalation bronchial challenge in 12 patients with atopic asthma. This was found to result in reproducible experimental asthma. Lodoxamide tromethamine was administered by inhalation in two different doses, 0.01 mg and 0.1 mg, to each patient, in double-blind, random, placebo-controlled manner, 15 minutes before pollen inhalation. It was found to have a significant protective action at both doses (p less than 0.05), but it produced troublesome side effects at the higher dose of 0.1 mg.
摘要
高度纯化的种属特异性草花粉抗原被用于对12例特应性哮喘患者进行吸入支气管激发试验。结果发现这会导致可重复的实验性哮喘。在花粉吸入前15分钟，以双盲、随机、安慰剂对照的方式，给每位患者吸入两种不同剂量（0.01毫克和0.1毫克）的三甲噻胺氯苯吡醇。结果发现两种剂量均具有显著的保护作用（p小于0.05），但0.1毫克的较高剂量会产生令人烦恼的副作用。
相似文献
1
Inhalation challenge with specific grass pollen antigens in asthmatics and the effect of lodoxamide tromethamine.哮喘患者吸入特定草花粉抗原的激发试验及三甲噻米哒洛草酰胺的作用
Thorax. 1983 Jun;38(6):458-62. doi: 10.1136/thx.38.6.458.
2
Protective effect opf lodoxamide tromethamine on allergen inhalation challenge.色甘酸二乙胺对吸入变应原激发的保护作用 。
你提供的原文中“opf”应该是“of”的错误拼写。
J Allergy Clin Immunol. 1980 Oct;66(4):286-94. doi: 10.1016/0091-6749(80)90023-8.
3
The effect of lodoxamide tromethamine on the immediate asthmatic response to allergen provocation.
Clin Allergy. 1982 Nov;12(6):587-94. doi: 10.1111/j.1365-2222.1982.tb02557.x.
4
Effect of inhaled iodoxamide tromethamine in prevention of antigen-induced bronchospasm.
J Allergy Clin Immunol. 1981 Dec;68(6):471-8. doi: 10.1016/0091-6749(81)90201-3.
5
Inhaled lodoxamide tromethamine in the treatment of perennial asthma: a double-blind placebo-controlled study.
J Allergy Clin Immunol. 1985 Jul;76(1):83-90. doi: 10.1016/0091-6749(85)90808-5.
6
The characterization of lodoxamide, a very active inhibitor of mediator release, in animal and human models of asthma.洛度沙胺（一种非常有效的介质释放抑制剂）在哮喘动物和人体模型中的特性研究。
Agents Actions. 1986 Jun;18(3-4):301-5. doi: 10.1007/BF01964988.
7
Lodoxamide tromethamine treatment for superior limbic keratoconjunctivitis.
Am J Ophthalmol. 1995 Sep;120(3):400-2. doi: 10.1016/s0002-9394(14)72177-4.
8
9
[Alomide, a preventive immunopharmaceutical agent, in the treatment of ocular atopy].
Cesk Slov Oftalmol. 1998 Jan;54(1):41-5.
10
Effects of lodoxamide tromethamine on paraplegia that occurs after infrarenal aortic occlusion in the rabbit.
J Vasc Surg. 1987 Dec;6(6):572-7.
引用本文的文献
1
Allergic eye disease mechanisms.过敏性眼病机制。
Br J Ophthalmol. 1998 Oct;82(10):1203-14. doi: 10.1136/bjo.82.10.1203.
2
Treatment of common ocular allergic disorders; a comparison of lodoxamide and NAAGA.常见眼部过敏性疾病的治疗；洛度沙胺与NAAGA的比较
Br J Ophthalmol. 1998 Oct;82(10):1135-8. doi: 10.1136/bjo.82.10.1135.
本文引用的文献
1
Protective effect opf lodoxamide tromethamine on allergen inhalation challenge.色甘酸二乙胺对吸入变应原激发的保护作用 。
你提供的原文中“opf”应该是“of”的错误拼写。
J Allergy Clin Immunol. 1980 Oct;66(4):286-94. doi: 10.1016/0091-6749(80)90023-8.
2
Effect of iodoxamide ethyl on allergy skin tests.
J Allergy Clin Immunol. 1980 Apr;65(4):257-62. doi: 10.1016/0091-6749(80)90152-9.
3
Effect of inhaled iodoxamide tromethamine in prevention of antigen-induced bronchospasm.
J Allergy Clin Immunol. 1981 Dec;68(6):471-8. doi: 10.1016/0091-6749(81)90201-3.
4
5
Inhibition of eosinophil chemotaxis by the antagonist of slow reacting substance of anaphylaxis--compound FPL 55712.
J Pharm Pharmacol. 1974 Nov;26(11):917-8. doi: 10.1111/j.2042-7158.1974.tb09208.x.
6
Mechanisms of bronchial hyperreactivity in normal subjects after upper respiratory tract infection.上呼吸道感染后正常受试者支气管高反应性的机制
Am Rev Respir Dis. 1976 Feb;113(2):131-9. doi: 10.1164/arrd.1976.113.2.131.
7
Standardization of bronchial inhalation challenge procedures.支气管吸入激发试验程序的标准化。
J Allergy Clin Immunol. 1975 Oct;56(4):323-7. doi: 10.1016/0091-6749(75)90107-4.
8
Allergen-induced increase in non-allergic bronchial reactivity.变应原诱导的非过敏性支气管反应性增加。
Clin Allergy. 1977 Nov;7(6):503-13. doi: 10.1111/j.1365-2222.1977.tb01481.x.
9
Recurrent nocturnal asthmatic reactions to bronchial provocation tests.
Clin Allergy. 1979 May;9(3):213-9. doi: 10.1111/j.1365-2222.1979.tb01544.x.
10
Inhibition of allergic reactions by cromoglycate and by a new antiallergy drug U-42,585E. II. Activity in primates against aerosolized Ascaris suum antigen.色甘酸酯及新型抗过敏药物U - 42,585E对过敏反应的抑制作用。II. 在灵长类动物中对雾化猪蛔虫抗原的活性。
Int Arch Allergy Appl Immunol. 1978;56(6):481-7. doi: 10.1159/000232062.
Zotero 插件