哮喘患者吸入特定草花粉抗原的激发试验及三甲噻米哒洛草酰胺的作用
Inhalation challenge with specific grass pollen antigens in asthmatics and the effect of lodoxamide tromethamine.
作者信息
Parrish R W, Davies B H
出版信息
Thorax. 1983 Jun;38(6):458-62. doi: 10.1136/thx.38.6.458.
Abstract
Highly purified species-specific grass pollen antigens were used for inhalation bronchial challenge in 12 patients with atopic asthma. This was found to result in reproducible experimental asthma. Lodoxamide tromethamine was administered by inhalation in two different doses, 0.01 mg and 0.1 mg, to each patient, in double-blind, random, placebo-controlled manner, 15 minutes before pollen inhalation. It was found to have a significant protective action at both doses (p less than 0.05), but it produced troublesome side effects at the higher dose of 0.1 mg.
摘要
高度纯化的种属特异性草花粉抗原被用于对12例特应性哮喘患者进行吸入支气管激发试验。结果发现这会导致可重复的实验性哮喘。在花粉吸入前15分钟，以双盲、随机、安慰剂对照的方式，给每位患者吸入两种不同剂量（0.01毫克和0.1毫克）的三甲噻胺氯苯吡醇。结果发现两种剂量均具有显著的保护作用（p小于0.05），但0.1毫克的较高剂量会产生令人烦恼的副作用。
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