Johnson H G, VanHout C A, Wright J B
Int Arch Allergy Appl Immunol. 1978;56(6):481-7. doi: 10.1159/000232062.
Immediate type hypersensitivity to Ascaris antigen in Rhesus reactor monkeys was used to assess the pharmacologic profile of cromolyn Na (DSCG) and a new inhibitor of IgE-mediated lung function changes (U-42,585E). Two parameters used to measure lung function, respiratory rate increase and tidal volume decrease, were significantly altered in a dose-related fashion by U-42,585E when the latter was administered either by the intravenous, intrabronchial, or the oral route. Oral activity of U-42,585E was demonstrated with doses as low as 5 mg/kg in Ascaris reactor primates.
利用恒河猴对蛔虫抗原的速发型超敏反应，来评估色甘酸钠（DSCG）和一种新型IgE介导的肺功能变化抑制剂（U-42,585E）的药理学特征。当通过静脉内、支气管内或口服途径给予U-42,585E时，用于测量肺功能的两个参数，即呼吸频率增加和潮气量减少，会以剂量相关的方式发生显著改变。在蛔虫反应性灵长类动物中，低至5mg/kg的剂量就证明了U-42,585E的口服活性。
