Villalobos-Molina R, García-Sáinz J A
Eur J Pharmacol. 1983 Jun 17;90(4):457-9. doi: 10.1016/0014-2999(83)90573-3.
Histamine and 2-(2-aminoethyl)-thiazole induced dose-dependent increases in the labeling of phosphatidylinositol in rabbit aorta whereas impromidine was without effect. The effect of histamine was inhibited by antihistamines with the following order of potency: mepyramine greater than or equal to pyrilamine much greater than cimetidine. The data indicate that H1-histaminergic activation stimulates phosphatidylinositol labeling in rabbit aorta and suggest the involvement of a calcium-signaling process in the action of H1-histaminergic receptors.
组胺和2-(2-氨基乙基)-噻唑可使兔主动脉中磷脂酰肌醇的标记呈剂量依赖性增加，而英普咪定则无此作用。组胺的作用可被抗组胺药抑制，其效力顺序如下：美吡拉敏≥吡苄明远大于西咪替丁。这些数据表明，H1组胺能激活刺激兔主动脉中磷脂酰肌醇的标记，并提示钙信号传导过程参与H1组胺能受体的作用。
