夏季月份中乙酰胆碱对阿托品化青蛙心脏的作用。
Action of acetylcholine on the atropinised heart of the frog during summer months.
作者信息
Mediratta P K, Prabhu S, Prasad S, Singh G
出版信息
Indian J Physiol Pharmacol. 1983 Apr-Jun;27(2):161-5.
PMID:6136461
Abstract
During summer months high doses of acetylcholine produced positive inotropic and chronotropic actions in 19 out of 22 preparations of atropinised perfused heart of the frog. Hexamethonium failed to block both the positive inotropic and chronotropic actions of Ach. Interestingly another ganglion blocking agent mecamylamine as well as beta adrenergic blocking agent propranolol blocked the positive inotropic action but not the positive chronotropic action.
摘要
在夏季，高剂量的乙酰胆碱在22个阿托品化的蛙类灌注心脏标本中的19个中产生了正性肌力和正性变时作用。六甲铵未能阻断乙酰胆碱的正性肌力和正性变时作用。有趣的是，另一种神经节阻断剂美加明以及β肾上腺素能阻断剂普萘洛尔阻断了正性肌力作用，但未阻断正性变时作用。
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