DeMarinis R M, Hieble J P
J Med Chem. 1983 Sep;26(9):1215-8. doi: 10.1021/jm00363a002.
1,2,3,4-Tetrahydro-8-methoxy-5-(methylthio)-2-naphthalenamine (SK&F-89748) has been resolved into d and l enantiomers and characterized pharmacologically. The more active isomer is the l, which has the S configuration as established by single-crystal X-ray diffraction studies. This compound is a potent and selective alpha 1-agonist with an EC50 in the isolated perfused rabbit ear artery of 9 +/- 2 nM. In several preparations, it has shown an alpha 1/alpha 2 selectivity ratio of over 100 and will be a useful tool for characterizing receptor subtypes.
1,2,3,4-四氢-8-甲氧基-5-(甲硫基)-2-萘胺（SK&F-89748）已被拆分为d型和l型对映体并进行了药理学表征。活性更强的异构体是l型，通过单晶X射线衍射研究确定其具有S构型。该化合物是一种强效且选择性的α1-激动剂，在离体灌注兔耳动脉中的EC50为9±2 nM。在几种制剂中，它的α1/α2选择性比率超过100，将成为表征受体亚型的有用工具。
