非洲爪蟾卵母细胞中外源信使核糖核酸翻译的单个γ-氨基丁酸和乙酰胆碱激活受体通道的记录。
Recording of single gamma-aminobutyrate- and acetylcholine-activated receptor channels translated by exogenous mRNA in Xenopus oocytes.
作者信息
Miledi R, Parker I, Sumikawa K
出版信息
Proc R Soc Lond B Biol Sci. 1983 Jul 22;218(1213):481-4. doi: 10.1098/rspb.1983.0053.
PMID:6136979
Abstract
High resolution ('giga-seal') patch clamp recording in Xenopus oocytes was used to measure single channel currents from ACh- and GABA-activated receptors. The proteins that make up these receptors had been translated from mRNA derived from, respectively, denervated cat muscle and chick optic lobe.
摘要
利用非洲爪蟾卵母细胞中的高分辨率（“千兆封接”）膜片钳记录技术来测量乙酰胆碱和γ-氨基丁酸激活受体的单通道电流。构成这些受体的蛋白质分别是由取自去神经支配的猫肌肉和鸡视叶的信使核糖核酸翻译而来的。
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