Del Soldato P, Varin L
Pharmacol Res Commun. 1983 May;15(5):473-84. doi: 10.1016/s0031-6989(83)80067-8.
The ability of H2-receptor antagonists (cimetidine, ranitidine, tiotidine) and antimuscarinic agents (atropine and pirenzepine) to prevent gastric damage induced by acetylsalicylic acid (ASA) was determined in stressed rats. The results obtained were as follows: 1) H2-receptor antagonists were ineffective; 2) antimuscarinic agents significantly reduced the gastric pathology in a dose-related manner. These findings are discussed in an attempt to elucidate the mechanism(s) involved in the pathogenesis of ASA-induced gastric damage in stressed rats.
在应激大鼠中测定了H2受体拮抗剂（西咪替丁、雷尼替丁、替奥替丁）和抗毒蕈碱药物（阿托品和哌仑西平）预防乙酰水杨酸（ASA）所致胃损伤的能力。获得的结果如下：1）H2受体拮抗剂无效；2）抗毒蕈碱药物以剂量相关方式显著减轻胃部病变。对这些发现进行了讨论，以试图阐明应激大鼠中ASA诱导胃损伤发病机制所涉及的机制。
