前列腺素E2与雷尼替丁预防阿司匹林所致人体胃出血的比较。
Comparison of prostaglandin E2 and ranitidine in prevention of gastric bleeding by aspirin in man.
作者信息
Konturek S J, Kwiecień N, Obtułowicz W, Polański M, Kopp B, Oleksy J
出版信息
Gut. 1983 Feb;24(2):89-93. doi: 10.1136/gut.24.2.89.
Abstract
This study was designed to compare the effect of oral administration of PGE2 (0.5 mg/kg) and ranitidine in larger (100 mg/dose) or smaller (10 mg/dose) doses on aspirin-induced gastric microbleeding and DNA loss determined chemically in gastric washings in eight healthy subjects. Aspirin (0.5 g) given four times daily greatly increased the rate of gastric bleeding and DNA loss and pretreatment with PGE2 or ranitidine in larger doses almost completely prevented these changes. Smaller non-antisecretory doses of ranitidine also reduced the rate of bleeding and DNA loss but to a lesser degree than PGE2. This study confirms that oral PGE2 has a protective action on gastric mucosa exposed to aspirin and that this property is also shared by ranitidine, a potent histamine H2-receptor antagonist.
摘要
本研究旨在比较口服前列腺素E2（PGE2，0.5毫克/千克）以及较大剂量（100毫克/剂）或较小剂量（10毫克/剂）雷尼替丁对8名健康受试者阿司匹林诱导的胃微出血及胃灌洗中化学测定的DNA损失的影响。每日4次给予阿司匹林（0.5克）显著增加胃出血率和DNA损失，大剂量PGE2或雷尼替丁预处理几乎完全防止了这些变化。较小的、无抑酸作用剂量的雷尼替丁也降低了出血率和DNA损失，但程度小于PGE2。本研究证实，口服PGE2对暴露于阿司匹林的胃黏膜具有保护作用，雷尼替丁（一种强效组胺H2受体拮抗剂）也具有此特性。
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本文引用的文献
1
The regulation of gastric emptying of meals containing citric acid and salts of citric acid.含柠檬酸及柠檬酸盐餐食的胃排空调节
J Physiol. 1962 Aug;163(1):34-45. doi: 10.1113/jphysiol.1962.sp006957.
2
THE ESTIMATION OF DEOXYRIBONUCLEIC ACID IN THE PRESENCE OF SIALIC ACID: APPLICATION TO ANALYSIS OF HUMAN GASTRIC WASHINGS.在唾液酸存在的情况下对脱氧核糖核酸的估计：在人胃冲洗液分析中的应用。
Biochem J. 1965 Jun;95(3):612-20. doi: 10.1042/bj0950612.
3
ASPIRIN AND THE EXFOLIATION OF GASTRIC EPITHELIAL CELLS. CYTOLOGICAL AND BIOCHEMICAL OBSERVATIONS.阿司匹林与胃上皮细胞的脱落。细胞学与生物化学观察
Br Med J. 1963 Oct 12;2(5362):897-901. doi: 10.1136/bmj.2.5362.892.
4
Aspirin and gastrointestinal bleeding. Chromate blood loss studies.阿司匹林与胃肠道出血。铬酸盐失血研究。
Am J Med. 1961 Aug;31:259-65. doi: 10.1016/0002-9343(61)90114-0.
5
Role of prostaglandins in the formation of aspirin-induced gastric ulcers.前列腺素在阿司匹林所致胃溃疡形成中的作用。
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Ann Rheum Dis. 1980 Jun;39(3):275-8. doi: 10.1136/ard.39.3.275.
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