西咪替丁和雷尼替丁的胆碱能效应。
Cholinergic effects of cimetidine and ranitidine.
作者信息
Re L, Cingolani M L, Concettoni C, Rossini L
出版信息
Pharmacol Res Commun. 1983 May;15(5):485-517. doi: 10.1016/s0031-6989(83)80068-x.
Cimetidine and ranitidine were submitted to eight in vitro assays: their intrinsic activity was evaluated on guinea-pig auricles and ileum, acetylcholine synergism on guinea-pig tracheal muscle, frog rectus abdominis, guinea-pig vas and rat phrenic nerve diaphragm, and antagonism on guinea-pig auricles and rat jejunum estimated at a range of concentrations. Ranitidine alone opposed 1-hyoscyamine antagonism in guinea-pig ileum when acetylcholine was the agonist, but not when the agonist was bethanechol.
西咪替丁和雷尼替丁进行了八项体外试验
在豚鼠耳廓和回肠上评估它们的内在活性，在豚鼠气管肌、蛙腹直肌、豚鼠血管和大鼠膈神经膈肌上评估乙酰胆碱协同作用，以及在一系列浓度下评估对豚鼠耳廓和大鼠空肠的拮抗作用。当乙酰胆碱作为激动剂时，单独使用雷尼替丁可对抗豚鼠回肠中1-莨菪碱的拮抗作用，但当激动剂为氨甲酰甲胆碱时则不然。
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