Theiss I, Basler A, Röhrborn G
Teratog Carcinog Mutagen. 1983;3(3):219-30. doi: 10.1002/1520-6866(1990)3:3<219::aid-tcm1770030302>3.0.co;2-5.
The effect of ethylnitrosourea (ENU) on chromosomes of mouse bone marrow cells and transplacentally exposed embryonic liver cells was investigated. Chromosome aberrations were found to be dose- and time-dependent. The maximum damage was seen 6 h after the exposure. Chromosome aberrations were also induced in bone marrow cells and lymphocytes of marmosets (Callithrix jacchus) directly exposed to ENU. Aberrations did not, however, occur in offspring whose mothers were treated with ENU before conception. Furthermore, chronic transplacentally exposed offspring have been analyzed. The frequency of chromosome aberrations was not increased in their lymphocytes and fibroblasts. The elimination of chromosome aberrations during embryogenesis is discussed.
研究了乙基亚硝基脲（ENU）对小鼠骨髓细胞和经胎盘暴露的胚胎肝细胞染色体的影响。发现染色体畸变呈剂量和时间依赖性。暴露后6小时可见最大损伤。直接暴露于ENU的狨猴（Callithrix jacchus）的骨髓细胞和淋巴细胞中也诱导出了染色体畸变。然而，在受孕前其母亲接受ENU治疗的后代中并未出现畸变。此外，还对经胎盘长期暴露的后代进行了分析。其淋巴细胞和成纤维细胞中的染色体畸变频率并未增加。文中讨论了胚胎发生过程中染色体畸变的消除情况。
