Bern M M, Klumpar D I, Wheeler W E, Davis G L
Thromb Res. 1983 Jul 1;31(1):177-86. doi: 10.1016/0049-3848(83)90018-x.
Chronic renal failure causes elevations of factor VIII coagulant activity and Factor VIII-related antigen even before the patients enter chronic hemodialysis. The change from control of Factor VIII ristocetin cofactor does not reach significance. The elevations are not effected by entering onto hemodialysis. These parameters are the same for non-diabetic and diabetic patients. Protein C, plasminogen and total fibrinolytic capacity are normal in diabetic and non-diabetic patients, with or without hemodialysis for chronic renal failure. However, before entering onto hemodialysis some of these parameters had negative correlation coefficients with parts of the factor VIII complex among the diabetic and non-diabetic patients. These negative correlates turned positive after hemodialysis. Thus, there are differences in these catabolic mechanisms for factor VIII when hemodialysis is used for diabetic and non-diabetic patients with chronic renal failure.
慢性肾衰竭甚至在患者进入慢性血液透析之前就会导致凝血因子VIII促凝活性和VIII因子相关抗原升高。VIII因子瑞斯托霉素辅因子水平与对照组相比变化不显著。这些升高不受开始血液透析的影响。非糖尿病患者和糖尿病患者的这些参数相同。无论是否因慢性肾衰竭进行血液透析，糖尿病患者和非糖尿病患者的蛋白C、纤溶酶原和总纤溶能力均正常。然而，在开始血液透析之前，糖尿病患者和非糖尿病患者中这些参数中的一些与VIII因子复合物的部分指标呈负相关系数。血液透析后这些负相关变为正相关。因此，对于患有慢性肾衰竭的糖尿病患者和非糖尿病患者，使用血液透析时VIII因子的这些分解代谢机制存在差异。
