Wegmüller E, Grüninger U, Furlan M, Beck E A, Hodler J, Reubi F C
Nephron. 1981;28(4):157-62. doi: 10.1159/000182161.
F VIII coagulant, F VIII-related antigen and F VIII ristocetin cofactor activity were significantly increased in 68 patients with various chronic renal diseases. All three F VIII functions correlated generally well with each other. A striking relationship between some F VIII activities and serum creatinine was detectable in patients with glomerulonephritis and kidney transplants, with mild or moderate renal insufficiency. This correlation was no longer present in terminal renal failure. The results suggest that in initial stages of renal disease elevated F VIII levels may be attributable to glomerular endothelial damage. In terminal renal failure, however, increased F VIII concentrations seem to result from nonspecific causes related to uremia such as acute phase reactions.
在68例各种慢性肾脏疾病患者中，F VIII凝血因子、F VIII相关抗原及F VIII瑞斯托霉素辅因子活性均显著升高。F VIII的这三项功能通常彼此密切相关。在患有肾小球肾炎和肾移植且伴有轻度或中度肾功能不全的患者中，可检测到某些F VIII活性与血清肌酐之间存在显著关系。而在终末期肾衰竭患者中，这种相关性不再存在。结果表明，在肾脏疾病的初始阶段，F VIII水平升高可能归因于肾小球内皮损伤。然而，在终末期肾衰竭时，F VIII浓度升高似乎是由与尿毒症相关的非特异性原因引起的，如急性期反应。
