泌乳大鼠乳腺和肝脏中食物摄入量及脂肪生成的昼夜变化。
Diurnal variations in food intake and in lipogenesis in mammary gland and liver of lactating rats.
作者信息
Munday M R, Williamson D H
出版信息
Biochem J. 1983 Jul 15;214(1):183-7. doi: 10.1042/bj2140183.
Abstract
Despite the hyperphagia, the food intake of the lactating rat showed marked diurnal changes which paralleled those of virgin rats. The major difference was that lactating rats consumed a higher proportion (35%) of their diet during the light period than did virgin rats (14%). The peak rate of lipogenesis in the lactating mammary gland occurred around midnight, and this decreased by 67% to reach a nadir around mid-afternoon; this corresponded with the period of lowest food intake. The diurnal variations in hepatic lipogenesis in lactating rats were much less marked. The changes in hepatic glycogen over 24 h suggest that it acts to supply carbon for lipogenesis during the period of decreased food intake. The activation state of acetyl-CoA carboxylase in mammary gland altered during 24 h, but the changes did not always correlate with alterations in the rate of lipogenesis. The changes in plasma insulin concentration tended to parallel the food intake in the lactating rats, but they did not appear to be sufficient to explain the large alterations in lipogenic rate in the mammary gland.
摘要
尽管哺乳期大鼠存在多食现象，但其食物摄入量呈现出明显的昼夜变化，这与未生育的大鼠相似。主要差异在于，哺乳期大鼠在光照期摄入的食物占其饮食的比例（35%）高于未生育的大鼠（14%）。哺乳期乳腺中脂肪生成的峰值速率出现在午夜左右，到下午中段左右降至最低点，下降了67%；这与食物摄入量最低的时期相对应。哺乳期大鼠肝脏脂肪生成的昼夜变化则不太明显。24小时内肝脏糖原的变化表明，在食物摄入量减少期间，它起到为脂肪生成提供碳源的作用。乳腺中乙酰辅酶A羧化酶的激活状态在24小时内发生了变化，但这些变化并不总是与脂肪生成速率的改变相关。哺乳期大鼠血浆胰岛素浓度的变化倾向于与食物摄入量平行，但似乎不足以解释乳腺中脂肪生成速率的大幅变化。
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Effects of inhibition of protein synthesis by cycloheximide on lipogenesis in mammary gland and liver of lactating rats.放线菌酮抑制蛋白质合成对泌乳大鼠乳腺和肝脏脂肪生成的影响。
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Role of pyruvate dehydrogenase and insulin in the regulation of lipogenesis in the lactating mammary gland of the rat during the starved-refed transition.饥饿-再喂养过渡期大鼠泌乳乳腺中丙酮酸脱氢酶和胰岛素在脂肪生成调节中的作用
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Impaired lipogenesis in mammary glands of lactating rats fed on a cafeteria diet. Reversal of inhibition of glucose metabolism in vitro by insulin.喂食自选饮食的泌乳大鼠乳腺中脂肪生成受损。胰岛素在体外逆转葡萄糖代谢抑制作用。
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10
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