Erickson A H, Walter P, Blobel G
Biochem Biophys Res Commun. 1983 Aug 30;115(1):275-80. doi: 10.1016/0006-291x(83)91000-8.
Signal recognition particle (SRP), an 11S ribonucleoprotein (Walter and Blobel (1982) Nature 299, 691-698), is required for translocation of secretory proteins across microsomal membranes (Walter and Blobel (1980) Proc. Natl. Acad. Sci. USA 77, 7112-7116) and for asymmetric integration into microsomal membranes of a transmembrane protein (Anderson et al., (1982) J. Cell Biol. 93, 501-506). We demonstrate here that SRP is also required for translocation of the lysosomal protease cathepsin D across microsomal membranes.
信号识别颗粒(SRP)是一种11S核糖核蛋白(沃尔特和布洛贝尔,《自然》,1982年,第299卷,第691 - 698页),分泌蛋白跨微粒体膜转运(沃尔特和布洛贝尔,《美国国家科学院院刊》,1980年,第77卷,第7112 - 7116页)以及跨膜蛋白不对称整合到微粒体膜中(安德森等人,《细胞生物学杂志》,1982年,第93卷,第501 - 506页)都需要它。我们在此证明,溶酶体蛋白酶组织蛋白酶D跨微粒体膜转运也需要SRP。