[Anxiolytic effect of potassium orotate].

Chronic administration of potassium orotate to rats per os in a dose of 100 mg/kg produces anxiolytic action that is manifested in antiaggressive, antiphobic and anti-conflict effects similar to the characteristic effects of diazepam. Besides, it provokes the changes in the spectral characteristics of the cat brain electrograms, common to tranquilizers. Based on the data obtained and analysis of the reported evidence the authors advance the hypothesis according to which endogenous pyrimidines, particularly orotic acid, possessing structural fragments necessary for the interaction with the sites of specific binding of 1,4-benzodiazepines may realize adaptive anxiolytic function both within the system of metabolic adaptation and when involved into the system of endogenous regulators and modulators of neuropsychic processes.