Weippl G, Mauracher E
Pharmatherapeutica. 1983;3(6):405-9.
An open study was carried out in 30 children with seasonal allergic rhinitis to evaluate the efficacy and tolerance of treatment with a dexbrompheniramine maleate (1.5 mg/5 ml) and pseudoephedrine sulphate (30 mg/5 ml) syrup formulation ('Disophrol' Syrup). Each patient was given 2.5 to 5 ml 4-times daily during the 14-day study period. Relief from signs and symptoms associated with seasonal rhinitis was evaluated on Days 7 and 14 of therapy. By Day 7, 5 patients were considered cured, 22 showed marked improvement and 3 patients had improved. At the Day 14 evaluation, 27 patients had complete clearing of signs and symptoms, 2 patients showed a marked improvement while the remaining patient was considered a treatment failure. Body weight and vital signs remained unaffected. Incidence of adverse reactions was limited to one occurrence of extreme fatigue, which did not necessitate termination of therapy.
对30名季节性变应性鼻炎患儿进行了一项开放性研究，以评估马来酸溴苯那敏（1.5毫克/5毫升）和硫酸伪麻黄碱（30毫克/5毫升）糖浆制剂（“Disophrol糖浆”）治疗的疗效和耐受性。在为期14天的研究期间，每名患者每日4次服用2.5至5毫升。在治疗的第7天和第14天评估与季节性鼻炎相关的体征和症状的缓解情况。到第7天，5名患者被认为治愈，22名显著改善，3名有所改善。在第14天评估时，27名患者的体征和症状完全消除，2名显著改善，其余1名患者被视为治疗失败。体重和生命体征未受影响。不良反应发生率仅限于1次出现极度疲劳，无需终止治疗。
