Berger J L, Depoix J P, Demetriou M, Lavaud E, Duvaldestin P
Ann Fr Anesth Reanim. 1983;2(1):17-22. doi: 10.1016/s0750-7658(83)80044-6.
The muscle relaxant effects of ORG NC 45 and pancuronium were compared in anesthetized patients with normal liver and renal functions. In all patients, the muscle relaxant effect was monitored by measuring the strength of the adductor pollicis muscle elicited by supramaximal stimulation of the ulnar nerve at the wrist. Different modes of administration of the muscle relaxants were used. In order to facilitate tracheal intubation, a dose of 100 mu X kg-1 of ORG NC 45 or pancuronium was administered. This dose was followed or not according to the type of surgery by repeated doses of 25 micrograms X kg-1. The results of this study indicate that ORG NC 45 is much shorter acting than pancuronium, and non cumulative. The dose of 100 micrograms X kg-1 produced adequate conditions for tracheal intubation 3 to 4 min after the administration of the muscle relaxant. The recovery of the muscle strength to 75% of control value was achieved 46 min and 100 min after a single dose of 100 micrograms X kg-1 of ORG NC 45 and pancuronium respectively. The interval of time between repeat injections averaged 20 min for ORG NC 45 and 40 min for pancuronium.
在肝功能和肾功能正常的麻醉患者中比较了ORG NC 45和潘库溴铵的肌松效果。在所有患者中，通过测量腕部尺神经超强刺激引起的拇内收肌力量来监测肌松效果。使用了不同的肌松药给药方式。为便于气管插管，给予100μg/kg的ORG NC 45或潘库溴铵。根据手术类型，此剂量之后可重复给予25μg/kg的剂量。本研究结果表明，ORG NC 45的作用时间比潘库溴铵短得多，且无蓄积作用。100μg/kg的剂量在给予肌松药后3至4分钟产生了足够的气管插管条件。单次给予100μg/kg的ORG NC 45和潘库溴铵后，肌肉力量分别在46分钟和100分钟恢复至对照值的75%。ORG NC 45重复注射的平均时间间隔为20分钟，潘库溴铵为40分钟。
