d'Hollander A A, Agoston S, De Ville A, Cuvelier F
Br J Anaesth. 1983 Feb;55(2):131-4. doi: 10.1093/bja/55.2.131.
Twenty-five healthy adult patients undergoing general anaesthesia for elective surgery were randomly allocated to five groups (n = 5) and their mechanical isometric adductor pollicis activity (twitch height (TH)), was monitored. The patients in groups I, II and III received suxamethonium 1 mg kg-1 followed by Org NC 45 40 micrograms kg-1 5 min (group I), 15 min (group II) or 30 min (group III) after complete recovery from muscle paralysis. The patients in groups IV and V received only Org NC 45 and 80 micrograms kg-1, respectively. Mean maximum TH depression (about 42% of initial value in group IV and 5% in group V) decreased to less than 4% in groups I, II and III regardless of the time interval between the injections of suxamethonium and Org NC 45. Mean duration to 90% recovery of Org NC 45-induced blockade was prolonged in patients in groups I, II and III when compared with the patients in group IV (28 min v. 12 min).
25名接受择期手术全身麻醉的健康成年患者被随机分为五组（每组n = 5），监测其拇内收肌的机械性等长活动（颤搐高度（TH））。I组、II组和III组患者先静脉注射琥珀胆碱1 mg/kg，待肌松完全恢复后5分钟（I组）、15分钟（II组）或30分钟（III组），再静脉注射Org NC 45 40μg/kg。IV组和V组患者分别仅静脉注射Org NC 45 80μg/kg。无论琥珀胆碱和Org NC 45注射的时间间隔如何，I组、II组和III组的平均最大TH抑制率（IV组约为初始值的42%，V组为5%）均降至4%以下。与IV组患者相比，I组、II组和III组患者Org NC 45诱导的阻滞恢复至90%的平均时间延长（28分钟对12分钟）。
