Balacco-Gabrieli C, Salamanna S, Giuliani E, Mastrandrea G, Latorre M
Boll Soc Ital Biol Sper. 1983 Aug 30;59(8):1172-5.
The Authors state the results of their research on the modification of the aqueous humor caused by the instillation of the Clonidina to the concentrations of 0,I25% in a group of ten rabbits. The results of these studies illustrate the variations of pH, the ocular tone, the concentration of lactic and ascorbic acid. In all the rabbits examined Clonidina was instillated in the RE while in the LE distilled water was instillated for the control. For two hours from the beginning of the experiment, every IO minutes measurements of the ocular tone in both eyes were taken. At the end of the two hours a sample of aqueous humor was taken from the RE and LE; It was found that: I) The drugs produced a very quick and prolonged decrease of the ocular tone. 2) There are no significant variations in the pH or in the concentration of lactic acid. 3) There was a notable reduction of the concentration of ascorbic acid.
作者陈述了他们对一组十只兔子滴入浓度为0.125%的可乐定后房水变化情况的研究结果。这些研究结果表明了pH值、眼压、乳酸和抗坏血酸浓度的变化。在所有接受检查的兔子中，右眼滴入可乐定，左眼滴入蒸馏水作为对照。从实验开始后的两个小时内，每隔10分钟测量一次双眼的眼压。两小时结束时，从右眼和左眼采集房水样本；结果发现：1）药物使眼压迅速且持续降低。2）pH值或乳酸浓度没有显著变化。3）抗坏血酸浓度有显著降低。
