咪达唑仑与失眠患者的睡眠
Midazolam and sleep in insomniac patients.
作者信息
Monti J M, Debellis J, Alterwain P, D'Angelo L
出版信息
Br J Clin Pharmacol. 1983;16 Suppl 1(Suppl 1):87S-88S. doi: 10.1111/j.1365-2125.1983.tb02276.x.
The effects of midazolam (15 and 30 mg p.o.) on the sleep of insomniac patients were assessed by means of polysomnographic recordings. As compared with placebo, 15 mg midazolam significantly increased non-REM sleep while other objective measures of insomnia were only slightly modified. At the 30 mg dose, midazolam significantly decreased total wake time and wake time after sleep onset. On the other hand, total sleep and non-REM sleep time were increased. No development of tolerance was observed following 2 weeks of drug use.
通过多导睡眠图记录评估了咪达唑仑（口服15毫克和30毫克）对失眠患者睡眠的影响。与安慰剂相比，15毫克咪达唑仑显著增加了非快速眼动睡眠，而其他失眠客观指标仅有轻微改变。30毫克剂量时，咪达唑仑显著减少了总觉醒时间和睡眠起始后的觉醒时间。另一方面，总睡眠时间和非快速眼动睡眠时间增加。用药2周后未观察到耐受性的产生。
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