一种脑外多巴胺拮抗剂所致的类神经阻滞剂性厌食症。

Neuroleptic-like anorexia produced by an extra-cerebral DA antagonist.

作者信息

Willis G L, Smith G C, Kinchington P C

出版信息

Brain Res Bull. 1983 Jul;11(1):21-4. doi: 10.1016/0361-9230(83)90052-7.

Abstract

The effects of the DA receptor antagonists metoclopramide and pimozide on food and water intake in male Sprague Dawley rats were compared to those of domperidone, which does not cross the blood-brain barrier, in an attempt to determine whether any extracerebral DA receptors participate in neuroleptic induced anorexia. While metoclopramide caused only minor changes in food and water intake at the doses employed both pimozide and domperidone caused a significant reduction in food intake and water consumption 1 hr and 4 hr after injection during a 4 hr intake test. These results support the hypothesis that the nigrostriatal system may not be the system principally involved in the neuroleptic induced anorexia which occurs after the administration of these drugs.

摘要

将多巴胺（DA）受体拮抗剂胃复安和匹莫齐特对雄性斯普拉格-道利大鼠食物和水摄入量的影响，与不能穿过血脑屏障的多潘立酮的影响进行了比较，以确定是否有任何脑外DA受体参与抗精神病药物引起的厌食症。在4小时摄入量测试中，虽然胃复安在所使用的剂量下仅引起食物和水摄入量的轻微变化，但匹莫齐特和多潘立酮在注射后1小时和4小时均导致食物摄入量和饮水量显著减少。这些结果支持以下假设，即黑质纹状体系统可能不是这些药物给药后发生的抗精神病药物引起的厌食症的主要相关系统。