Merrill J C, Bray T M
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1983;75(2):395-8. doi: 10.1016/0742-8413(83)90213-x.
The degree of tissue covalent binding of 14C-3-methylindole metabolite in goat and rat pretreated with phenobarbital or 3-methylcholanthrene was compared. The effect of conjugating agents, i.e. glutathione (GSH), cysteine and sulfate, in reducing the degree of tissue covalent binding was measured. The degree of tissue covalent binding was significantly higher in the lung than the liver of goats. In rats, covalent binding was higher in the liver than the lung. Glutathione and cysteine were effective in decreasing the degree of in vitro covalent binding in both liver and lung tissues of goat and rat.
比较了用苯巴比妥或3-甲基胆蒽预处理的山羊和大鼠中14C-3-甲基吲哚代谢物的组织共价结合程度。测定了结合剂即谷胱甘肽（GSH）、半胱氨酸和硫酸盐在降低组织共价结合程度方面的作用。山羊肺组织中的组织共价结合程度显著高于肝脏。在大鼠中，肝脏中的共价结合高于肺。谷胱甘肽和半胱氨酸在降低山羊和大鼠肝脏及肺组织的体外共价结合程度方面均有效。
