大鼠晶状体中γ-谷氨酰转肽酶的体外研究
In vitro study of gamma-glutamyl transpeptidase in rat lens.
作者信息
Said R, Bonne C, Regnault F, Sincholle D
出版信息
Exp Eye Res. 1983 Sep;37(3):273-8. doi: 10.1016/0014-4835(83)90162-8.
PMID:6138274
Abstract
gamma-Glutamyl transpeptidase catalyzes the initial step in the utilization of glutathione. In the lens, this enzyme is accessible to externally supplied substrates. An efflux of glutathione from the lens occurs when it was incubated in saline. Inhibition of gamma-glutamyl-transpeptidase by L-serine-borate decreases the rate of glutathione breakdown in the external medium and the rate of its decline in the lens.
摘要
γ-谷氨酰转肽酶催化谷胱甘肽利用的第一步。在晶状体中，这种酶可接触到外部提供的底物。当晶状体在盐溶液中孵育时，谷胱甘肽会从晶状体中流出。L-丝氨酸-硼酸盐对γ-谷氨酰转肽酶的抑制作用降低了外部介质中谷胱甘肽的分解速率及其在晶状体中的下降速率。
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