Antonenko V D, Popova S V, Panchenko L F
Farmakol Toksikol. 1983 Sep-Oct;46(5):86-90.
Male rats were fed ethanol as a constituent of an isocaloric diet. Ethanol administration caused hypercholesterolemia and accumulation of lipids in the liver. However, it did not alter enzymatic activity of fatty acids and cholesterol catabolism in the organ. Addition of the hypolipemic agent clofibrate to the ethanol-containing diet reduced the adverse effects of ethanol on lipid metabolism due to activation of peroxisomal and mitochondrial enzymes involved in oxidative degradation of lipids in the liver cell.
雄性大鼠被喂食含有乙醇的等热量饮食。给予乙醇会导致高胆固醇血症和肝脏中脂质的积累。然而，它并未改变该器官中脂肪酸和胆固醇分解代谢的酶活性。在含乙醇的饮食中添加降血脂药物氯贝丁酯，由于激活了参与肝细胞脂质氧化降解的过氧化物酶体和线粒体酶，减少了乙醇对脂质代谢的不利影响。
