抗抑郁药过量所致惊厥发作：病例报告与讨论

Convulsive attacks due to antidepressant drug overdoses: case reports and discussion.

作者信息

Flechter S, Rabey J M, Regev I, Borenstein N, Vardi J

出版信息

Gen Hosp Psychiatry. 1983 Sep;5(3):217-21. doi: 10.1016/0163-8343(83)90061-0.

Abstract

Antidepressant drug overdoses have been reported to induce seizures, but the etiology of this phenomenon is still unclear. Recently we treated three patients who suffered from epileptic seizures after acute overdoses of three antidepressant drugs: (a) Dibenzepin HCl (Noveril), (b) Maprotiline HCl (Ludiomil), and (c) Clorimipramine (Anafranil). After a review of the pertinent literature, the possible role of antidepressant drugs in the genesis of epileptic seizures is discussed.

摘要

据报道，抗抑郁药物过量会引发癫痫发作，但这一现象的病因仍不清楚。最近我们治疗了三名患者，他们在急性过量服用三种抗抑郁药物后出现癫痫发作：（a）盐酸二苯氮䓬（诺弗利），（b）盐酸马普替林（路滴美），以及（c）氯米帕明（安拿芬尼）。在回顾相关文献后，讨论了抗抑郁药物在癫痫发作发生过程中的可能作用。