Brogmus K E, Lesch A
Evangelische Nervenklinik, Klinikbereich Neurologie, Remscheid-Lüttringhausen.
Psychiatr Prax. 1995 Mar;22(2):77-9.
Based on five case studies, the suggestion is that, if physiological myoclonus can be excluded, antidepressant - or neuroleptic-induced myoclonus must as a rule be presumed to be a most subtle indication of increased cerebral exitability, an epileptic fragment or, in some instances, a myoclonus epilepsy. In each of the reported cases EEG recordings reflected epilepsy-specific potentials. Whether, however, the scope of differences in the EEG recordings and the N1/P1 amplitude increase of the SSEP may be used as an additional diagnostic criterion to determine the risk of epileptic seizures, should depend on the type of myoclonus chiefly induced. This would require more extensive neurophysiological examinations which should mainly include the back-averaging to permit, beside the EEG, a better evaluation of the relatively easily obtainable SSEP findings.
基于五个案例研究，建议如下：如果可以排除生理性肌阵挛，那么抗抑郁药或抗精神病药所致肌阵挛通常必须被假定为大脑兴奋性增加的最细微迹象、癫痫片段，或在某些情况下为肌阵挛性癫痫。在所报告的每个案例中，脑电图记录均反映出癫痫特异性电位。然而，脑电图记录中的差异范围以及体感诱发电位的N1/P1波幅增加是否可用作确定癫痫发作风险的额外诊断标准，应取决于主要诱发的肌阵挛类型。这将需要更广泛的神经生理学检查，主要应包括反向平均法，以便除脑电图外，能更好地评估相对容易获得的体感诱发电位结果。
