强啡肽和新内啡肽肽在大鼠脑、脊髓和垂体中的区域分布。
Regional distribution of dynorphin and neo-endorphin peptides in rat brain, spinal cord, and pituitary.
作者信息
Cone R I, Weber E, Barchas J D, Goldstein A
出版信息
J Neurosci. 1983 Nov;3(11):2146-52. doi: 10.1523/JNEUROSCI.03-11-02146.1983.
Abstract
Five products of the dynorphin gene--alpha-neo-endorphin, beta-neo-endorphin, dynorphin A, dynorphin A-(1-8), and dynorphin B--were measured in various regions of rat brain and in rat spinal cord and pituitary. Specific antisera were used, supplemented by gel permeation analysis and high performance liquid chromatography, confirming the presence of dynorphin-32, dynorphin A, and dynorphin B in rat brain. In whole brain, alpha-neo-endorphin, dynorphin A-(1-8), and dynorphin B are present in much greater amounts than beta-neo-endorphin or dynorphin A. Although a general parallelism was found in the distribution of the five peptides, there were also noteworthy exceptions, suggesting that differential processing may occur.
摘要
在大鼠脑的不同区域、脊髓和垂体中检测了强啡肽基因的五种产物——α-新内啡肽、β-新内啡肽、强啡肽A、强啡肽A-(1-8)和强啡肽B。使用了特异性抗血清，并辅以凝胶渗透分析和高效液相色谱法，证实大鼠脑中存在强啡肽-32、强啡肽A和强啡肽B。在全脑中，α-新内啡肽、强啡肽A-(1-8)和强啡肽B的含量比β-新内啡肽或强啡肽A高得多。尽管在这五种肽的分布中发现了总体的平行性，但也有值得注意的例外情况，这表明可能发生了差异加工。
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