脱水对大鼠垂体神经中间叶中前强啡肽衍生肽的影响。
Effects of dehydration on pro-dynorphin derived peptides in the neuro-intermediate lobe of the rat pituitary.
作者信息
Lorenz R G, Evans C J, Barchas J D
出版信息
Life Sci. 1985 Oct 21;37(16):1523-8. doi: 10.1016/0024-3205(85)90184-5.
Dehydration significantly reduced the concentration of immunoreactive dynorphin A(1-17), dynorphin A(1-8), alpha-neo-endorphin, beta-neo-endorphin, and leu-enkephalin in the rat pituitary posterior-intermediate lobe. A statistically significant increase in immunoreactive dynorphin A(1-8), alpha-neo-endorphin and leu-enkephalin was observed in the hypothalamus. Comparison of the molar ratios of dynorphin A(1-17): dynorphin A(1-8) and alpha-neo-endorphin: beta-neo-endorphin showed an altered profile of stored pro-dynorphin cleavage products in the posterior-intermediate lobe of the pituitary of dehydrated rats.
脱水显著降低了大鼠垂体后叶-中间叶中免疫反应性强啡肽A(1-17)、强啡肽A(1-8)、α-新内啡肽、β-新内啡肽和亮氨酸脑啡肽的浓度。下丘脑内免疫反应性强啡肽A(1-8)、α-新内啡肽和亮氨酸脑啡肽出现了具有统计学意义的增加。强啡肽A(1-17)与强啡肽A(1-8)以及α-新内啡肽与β-新内啡肽的摩尔比比较显示，脱水大鼠垂体后叶-中间叶中储存的前强啡肽裂解产物的分布发生了改变。
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