Advenier C, Cerrina J, Floch A, Renier A, Duroux P
J Pharmacol. 1983 Jul-Sep;14(3):273-82.
The effects of nicardipine, verapamil and sodium cromoglycate (SCG) on the increase in pulmonary airway resistance (Raw) and decrease in pulmonary dynamic compliance (C.Dyn.) induced by histamine (Hist) (3 and 30 micrograms x kg-1, i.v.) and acetylcholine (ACh) (3 and 30 micrograms x kg-1, i.v.) were investigated in anaesthetized guinea-pigs. The effects of these three agents on the contractile effects of Hist and ACh were tested on isolated tracheal preparations of the guinea pig. Nicardipine (0.3 and 1 mg . kg-1, i.v.) and verapamil (1 mg . kg-1, i.v.) as well as SCG (3 and 10 mg . kg-1, i.v.) partially but significantly inhibited the effects of Hist on Raw. These substances had no effect on Hist-induced decrease in C.Dyn. Nicardipine and verapamil had no effect on ACh-induced bronchoconstriction in vivo. SCG partially but significantly inhibited the effects of ACh (30 micrograms . kg-1) on Raw. In concentrations higher than 3 x 10(-6) M, nicardipine and verapamil inhibited the contractile effects of Hist and ACh on guinea-pig isolated trachea. SCG had no effect on this preparation. The results suggest that nicardipine, verapamil and SCG partially reduce the component of bronchoconstriction associated with stimulation of irritant receptor by Hist. However, the site and mechanism of action of Ca++-entry antagonists remain uncertain.
在麻醉的豚鼠中，研究了尼卡地平、维拉帕米和色甘酸钠（SCG）对组胺（Hist）（3和30微克·千克⁻¹，静脉注射）和乙酰胆碱（ACh）（3和30微克·千克⁻¹，静脉注射）诱导的肺气道阻力（Raw）增加和肺动态顺应性（C.Dyn.）降低的影响。在豚鼠离体气管制备物上测试了这三种药物对Hist和ACh收缩作用的影响。尼卡地平（0.3和1毫克·千克⁻¹，静脉注射）、维拉帕米（1毫克·千克⁻¹，静脉注射）以及SCG（3和10毫克·千克⁻¹，静脉注射）部分但显著地抑制了Hist对Raw的作用。这些物质对Hist诱导的C.Dyn.降低没有影响。尼卡地平和维拉帕米对体内ACh诱导的支气管收缩没有影响。SCG部分但显著地抑制了ACh（30微克·千克⁻¹）对Raw的作用。在高于3×10⁻⁶ M的浓度下，尼卡地平和维拉帕米抑制了Hist和ACh对豚鼠离体气管的收缩作用。SCG对该制备物没有影响。结果表明，尼卡地平、维拉帕米和SCG部分降低了与Hist刺激刺激性受体相关的支气管收缩成分。然而，钙通道拮抗剂的作用部位和机制仍不确定。
