维拉帕米吸入对麻醉犬组胺诱导的支气管收缩具有不同的剂量依赖性效应。

Different, dose-dependent effects of verapamil inhalation on histamine-induced bronchoconstriction in anaesthetized dogs.

作者信息

Krivoy N, Brandt H D, Bunn A E

出版信息

Arch Int Pharmacodyn Ther. 1984 Feb;267(2):328-34.

Abstract

Different, dose-dependent effects of verapamil inhalation on histamine-induced bronchoconstriction in anaesthetized dogs are reported. Cumulative histamine dose-response curves were obtained on three groups each consisting of six dogs. These groups were: A - after atropine sulphate (1 mg/kg); B - after atropine sulphate and verapamil (approximately 0.5 mg/kg); C - after atropine sulphate and verapamil (approximately 5.0 mg/kg). Total lung resistance (R1) was measured as the indicator of bronchoconstriction. The mean maximal response of R1 in B was significant greater (p less than 0.01) than in A and C, while no significant difference was observed between A and C. A possible mechanism is postulated.

摘要

据报道，维拉帕米吸入对麻醉犬组胺诱导的支气管收缩有不同的剂量依赖性效应。在每组由六只犬组成的三个组上获得了累积组胺剂量-反应曲线。这些组分别为：A组——硫酸阿托品（1毫克/千克）给药后；B组——硫酸阿托品和维拉帕米（约0.5毫克/千克）给药后；C组——硫酸阿托品和维拉帕米（约5.0毫克/千克）给药后。测量总肺阻力（R1）作为支气管收缩的指标。B组中R1的平均最大反应显著大于A组和C组（p小于0.01），而A组和C组之间未观察到显著差异。推测了一种可能的机制。