Hervey G R, Hutchinson I, Knibbs A V, Burkinshaw L, Jones P R, Norgan N G, Levell M J
Lancet. 1976 Oct 2;2(7988):699-702. doi: 10.1016/s0140-6736(76)90001-5.
After failure to confirm an anabolic action of testosterone and its derivatives in rats, methandienone ('Dianabol', an "anabolic steroid" used by athletes) has been given to 11 athletic men during a course of weight-training, in a double-blind, crossover experiment. The dose of methandienone was 100 mg/day for 6 wk. Body weight and composition, muscular strength and performance, and indices of endocrine function were studied. Compared with the placebo period, on methandienone the subjects gained weight (mean 3-3 kg +/- 0-6 kg) and accumulated a disproportionately large amount of potassium (420+/-68 mmol); the increase in weight was confined to the lean part of the body, and the muscles increased in size. Strength and performance improved over each training period, but not significantly differently on drug and placebo. On the drug, plasma-cortisol concentration and urinary cortisol excretion increased, and plasma-testosterone decreased. Although the weight and body-composition changes may demonstrate an anabolic action of methandienone in man, they may alternatively have been caused by an increase in intracellular fluid, and the question of anabolic action therefore remains open.
在未能证实睾酮及其衍生物在大鼠体内具有合成代谢作用后，在一项双盲交叉实验中，对11名男性运动员在进行为期6周的重量训练期间给予了大力补（“大力补”，一种运动员使用的“合成代谢类固醇”）。大力补的剂量为每日100毫克，持续6周。研究了体重和身体成分、肌肉力量和表现以及内分泌功能指标。与使用安慰剂的时期相比，服用大力补期间受试者体重增加（平均3.3千克±0.6千克），并蓄积了大量不成比例的钾（420±68毫摩尔）；体重增加仅限于身体的瘦组织部分，肌肉体积增大。在每个训练阶段，力量和表现均有所改善，但使用药物和安慰剂时改善程度无显著差异。服用药物后，血浆皮质醇浓度和尿皮质醇排泄增加，血浆睾酮降低。尽管体重和身体成分的变化可能表明大力补在人体中具有合成代谢作用，但这些变化也可能是由细胞内液增加引起的，因此合成代谢作用的问题仍然悬而未决。
