Abstract
Tardive dyskinesia frequently occur during neuroleptic-treatments. Prevalence and risk factors, clinical characteristics, relation to other extrapyramidal disorders are reviewed. The presumed pathophysiology is that tardive dyskinesia are caused by a neuroleptic-induced dopamine receptor hypersensitivity. Several trials of treatment are compared with respect to this hypothesis.
摘要
迟发性运动障碍常在抗精神病药物治疗期间出现。本文综述了其患病率、危险因素、临床特征以及与其他锥体外系疾病的关系。推测的病理生理学机制是，迟发性运动障碍由抗精神病药物诱发的多巴胺受体超敏反应所致。针对这一假说，对多项治疗试验进行了比较。
相似文献
1
[Tardive dyskinesias].迟发性运动障碍
Encephale. 1983;9(2):151-66.
2
Tardive dyskinesia.迟发性运动障碍
Dan Med Bull. 1979 Aug;26(5):209-45.
3
[Tardive dyskinesia].
Minerva Med. 1985 Apr 14;76(16):797-802.
4
Drug-induced movement disorders.药物性运动障碍
Curr Opin Neurol Neurosurg. 1993 Jun;6(3):369-76.
5
Movement disorders with neuroleptic drug treatment.抗精神病药物治疗所致运动障碍
Psychiatr Clin North Am. 1984 Sep;7(3):453-71.
6
Coexistence of severe parkinsonism and tardive dyskinesia as side effects of neuroleptic therapy.严重帕金森症与迟发性运动障碍并存作为抗精神病药物治疗的副作用。
J Clin Psychiatry. 1984 Jan;45(1):28-30.
7
Tardive dyskinesia: review and update.迟发性运动障碍：综述与更新
Am J Psychiatry. 1980 Aug;137(8):900-8. doi: 10.1176/ajp.137.8.900.
8
[Tardive dyskinesia induced by neuroleptics. A review of the literature].
Encephale. 1979;5(4):317-37.
9
Tardive dyskinesia presenting as gastrointestinal disorder.迟发性运动障碍表现为胃肠道疾病。
J Clin Psychiatry. 1990 Jun;51(6):253-4.
10
An update on tardive dyskinesia.迟发性运动障碍的最新情况。
Hosp Community Psychiatry. 1986 Apr;37(4):362-9. doi: 10.1176/ps.37.4.362.
Zotero 插件