Basjrah R, Lubis H R, Tann G
J Int Med Res. 1983;11(5):263-8. doi: 10.1177/030006058301100503.
Administration of a beta-blocker, pindolol, was utilized in the premedication of patients selected for tonsillectomies (dissection), to study anxiolytic effects. A curious result observed was that bleeding during and after operation in patients on pindolol was remarkably reduced compared to those not on beta-blocker treatment. This effect was further explored in a small controlled study. Nineteen patients were given pindolol, 5 mg the evening before and on the morning, an hour prior to surgery. Seventeen controls were on placebos. The amount of bleeding was measured in both groups. Patients on pindolol show significantly reduced bleeding when compared to controls (1.77 +/- 1.15 ml versus 7.30 +/- 6.05 ml; p less than 0.005). Coagulation and fibrinolytic profiles were studied in a number of patients in both groups attempting to clarify the cause of the reduced bleeding. The results will be reported. This preliminary study shows that pindolol is a useful drug for controlling bleeding in tonsillectomies. To our knowledge the haemostatic properties of pindolol have been reported before.
在为扁桃体切除术（剥离术）选择的患者术前用药中使用了β受体阻滞剂吲哚洛尔，以研究其抗焦虑作用。观察到一个奇怪的结果是，与未接受β受体阻滞剂治疗的患者相比，服用吲哚洛尔的患者在手术期间及术后的出血明显减少。在一项小型对照研究中对这种效应进行了进一步探究。19名患者在手术前一晚及手术当天早上、手术前一小时服用5毫克吲哚洛尔。17名对照者服用安慰剂。对两组的出血量进行了测量。与对照组相比，服用吲哚洛尔的患者出血明显减少（1.77±1.15毫升对7.30±6.05毫升；p<0.005）。对两组中的一些患者研究了凝血和纤维蛋白溶解情况，试图阐明出血减少的原因。结果将予以报道。这项初步研究表明，吲哚洛尔是控制扁桃体切除术中出血的一种有用药物。据我们所知，吲哚洛尔的止血特性此前已有报道。
