吲哚洛尔、美托洛尔、阿替洛尔和拉贝洛尔治疗轻至中度高血压的双盲交叉对照研究
A double-blind crossover comparison of pindolol, metoprolol, atenolol and labetalol in mild to moderate hypertension.
作者信息
McNeil J J, Louis W J
出版信息
Br J Clin Pharmacol. 1979;8(Suppl 2):163S-166S.
Abstract
1 This study was designed to compare in a double-blind randomized crossover trial, atenolol, labetalol, metoprolol and pindolol. Considerable differences in dose (atenolol 138 +/- 13 mg daily; labetalol 308 +/- 34 mg daily; metoprolol 234 +/- 22 mg daily; and pindolol 24 +/-2 mg daily were required to produce similar antihypertensive effects. 3 The overall incidence of side-effects was similar with atenolol, metoprolol and pindolol but was slightly less with labetalol. Sleep disturbances and abnormal dreaming patterns were most frequent with pindolol. 4 There was a significantly greater fall in pulse rate during atenolol and metoprolol treatment periods.
摘要
1 本研究旨在通过双盲随机交叉试验比较阿替洛尔、拉贝洛尔、美托洛尔和吲哚洛尔。产生相似的降压效果所需剂量存在显著差异（阿替洛尔每日138±13毫克；拉贝洛尔每日308±34毫克；美托洛尔每日234±22毫克；吲哚洛尔每日24±2毫克）。3 阿替洛尔、美托洛尔和吲哚洛尔的副作用总发生率相似，但拉贝洛尔的副作用略少。吲哚洛尔引起的睡眠障碍和异常梦境最为常见。4 在阿替洛尔和美托洛尔治疗期间，脉搏率下降更为显著。
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