Felber J P, Thiébaud D, Maeder E, Jéquier E, Hendler R, DeFronzo R A
Diabetologia. 1983 Oct;25(4):325-30. doi: 10.1007/BF00253195.
In the basal state the body utilizes glucose at a rate of 2.2 - 2.3 mg.kg-1.min-1; of this approximately 1.2 - 1.3 mg.kg-1.min-1 is oxidized, while the remaining 1.0 mg.kg-1.min-1 must be utilized by non-oxidative pathways. Little information is, however, available concerning the insulin dependency of these processes. To examine the role of basal insulin levels on glucose oxidation, glucose storage and total body glucose uptake, somatostatin (10 microgram/min) was infused for 2 h in nine volunteers while maintaining plasma glucose concentration constant at basal levels by an exogenous glucose infusion. Basal plasma insulin fell by about 50% (13 +/- 2 to 7 +/- 1 mU/l, p less than 0.01). Total body glucose metabolism (3H-3-glucose) declined from 2.3 +/- 0.1 to 1.9 +/- 0.1 mg.kg-1.min-1 (p less than 0.01). This decrease was entirely accounted for by a fall in basal glucose oxidation (measured by indirect calorimetry) from 1.3 +/- 0.1 to 0.7 +/- 0.1 mg.kg-1.min-1 (p less than 0.001). To assess the specific role of insulin deficiency in the decline in glucose oxidation, subjects were restudied with somatostatin plus basal insulin replacement (0.07 mg.kg-1.min-1). Fasting insulin concentration (14 +/- 1 mU/l) remained constant during somatostatin plus insulin infusion (13 +/- 1 mU/l) and basal rates of glucose oxidation (1.2 +/- 0.1 mg.kg-1.min-1) and total body glucose uptake did not change significantly. After 2 h, the basal insulin infusion was stopped and somatostatin was continued. Over the subsequent hour, glucose oxidation declined by 0.4 +/- 0.1 mg.kg-1.min-1.(ABSTRACT TRUNCATED AT 250 WORDS)
在基础状态下，机体利用葡萄糖的速率为2.2 - 2.3毫克·千克⁻¹·分钟⁻¹；其中约1.2 - 1.3毫克·千克⁻¹·分钟⁻¹被氧化，而其余1.0毫克·千克⁻¹·分钟⁻¹必须通过非氧化途径利用。然而，关于这些过程对胰岛素的依赖性，目前所知甚少。为了研究基础胰岛素水平对葡萄糖氧化、葡萄糖储存和全身葡萄糖摄取的作用，对9名志愿者输注生长抑素（10微克/分钟）2小时，同时通过外源性输注葡萄糖使血浆葡萄糖浓度维持在基础水平不变。基础血浆胰岛素下降约50%（从13±2降至7±1毫单位/升，p<0.01）。全身葡萄糖代谢（³H-³-葡萄糖）从2.3±0.1降至1.9±0.1毫克·千克⁻¹·分钟⁻¹（p<0.01）。这种下降完全是由于基础葡萄糖氧化（通过间接测热法测量）从1.3±0.1降至0.7±0.1毫克·千克⁻¹·分钟⁻¹所致（p<0.001）。为了评估胰岛素缺乏在葡萄糖氧化下降中的具体作用，对受试者再次进行研究，同时输注生长抑素并补充基础胰岛素（0.07毫克·千克⁻¹·分钟⁻¹）。在输注生长抑素加胰岛素期间，空腹胰岛素浓度（14±1毫单位/升）保持不变（13±1毫单位/升），葡萄糖氧化基础速率（1.2±0.1毫克·千克⁻¹·分钟⁻¹）和全身葡萄糖摄取没有显著变化。2小时后，停止基础胰岛素输注，继续输注生长抑素。在随后的1小时内，葡萄糖氧化下降了0.4±0.1毫克·千克⁻¹·分钟⁻¹。（摘要截取自250字）
