Moreau S, Moulé Y, Bousquet J F
Ann Nutr Aliment. 1977;31(4-6):881-4.
Certain strains of Penicillium roqueforti and of Phoma exigua var. inoxydabilis synthesize eremophilane-like sesquiterpenes, some of which are biologically active. We have chosen a group of these compounds which are related chemically in order to study the relationships between their chemical structure and their biological properties (toxicity in vivo, capacity of inhibiting RNA and protein syntheses in eucaryotes). This work concerns PR toxin and 2 derived metabolites synthesized by P. roqueforti and phenomenone which is produced by P. exigua. The results allow us to discuss the problem of the active sites of these compounds.
某些罗克福特青霉和不氧化茎点霉变种的菌株能合成类桉叶烷倍半萜，其中一些具有生物活性。我们选择了一组在化学上相关的这些化合物，以研究它们的化学结构与生物学特性（体内毒性、抑制真核生物中RNA和蛋白质合成的能力）之间的关系。这项工作涉及罗克福特青霉合成的PR毒素和2种衍生代谢物以及茎点霉产生的现象。这些结果使我们能够讨论这些化合物的活性位点问题。
