Woolverton W L, Schuster C R
J Pharmacol Methods. 1983 Sep;10(2):93-106. doi: 10.1016/0160-5402(83)90072-4.
Rhesus monkeys were trained to self-administer psychoactive drugs by the intragastric route of administration under limited access conditions and intermittent schedules of drug delivery. Under a fixed-ratio 10 schedule, pentobarbital, diazepam, and cocaine maintained self-administration in some monkeys. Responding was not maintained by d-amphetamine under these conditions. Under fixed-ratio 10 (timeout 2 min) conditions, cocaine maintained self-administration in all animals (5/5) tested, while pentobarbital maintained responding in 2/3. At doses higher than that which maintained maximal rates, responding was inversely related to dose/injection. Drug intake was relatively constant across dose/injection of cocaine, but was a direct function of dose/injection of pentobarbital and diazepam. The procedure may be useful in assessing behavioral and pharmacological variables controlling oral self-administration of drugs.
恒河猴经过训练，可在有限获取条件和间歇性给药方案下通过胃内给药途径自行服用精神活性药物。在固定比例为10的给药方案下，戊巴比妥、地西泮和可卡因能维持部分猴子的自行给药行为。在这些条件下，右旋苯丙胺不能维持反应。在固定比例为10（超时2分钟）的条件下，可卡因能维持所有接受测试的动物（5/5）的自行给药行为，而戊巴比妥能维持2/3动物的反应。在高于维持最大反应率的剂量下，反应与剂量/注射量呈负相关。可卡因的药物摄入量在不同剂量/注射量之间相对恒定，但戊巴比妥和地西泮的药物摄入量是剂量/注射量的直接函数。该程序可能有助于评估控制药物口服自行给药的行为和药理学变量。
