Ikeda H, Sheardown M J
Vision Res. 1983;23(10):1161-74. doi: 10.1016/0042-6989(83)90030-5.
The effects of iontophoretically applied putative neurotransmitters and their antagonists on the responses of retinal ganglion cells were studied in the optically intact eye of anaesthetized cats. L-aspartate enhanced and a N-methyl-D-aspartate receptor blocker, 2-amino-5-phosphonovalerate, blocked visual excitations of "sustained" cells, whereas acetylcholine enhanced, and the nicotinic receptor blocker, dihydro-beta-erythroidine, blocked those of "transient" cells. GABA enhanced and bicuculline blocked inhibitions of on-centre cells, but glycine enhanced and strychnine blocked those of off-centre cells, whether the cells were "sustained" or "transient". The possibility that: (A) aspartate may be an excitatory transmitter at both "on-" and "off-sustained" cells and acetylcholine, at both "on-" and "off-transient" cells; (B) GABA may be an inhibitory transmitter for on-centre, and glycine, for off-centre cells, is discussed.
在麻醉猫的光学完整眼内，研究了离子电渗法施加的假定神经递质及其拮抗剂对视网膜神经节细胞反应的影响。L-天冬氨酸增强了“持续型”细胞的视觉兴奋，而N-甲基-D-天冬氨酸受体阻断剂2-氨基-5-磷酸戊酸则阻断了这种兴奋；乙酰胆碱增强了“瞬变型”细胞的视觉兴奋，而烟碱样受体阻断剂二氢-β-刺桐碱则阻断了这种兴奋。γ-氨基丁酸增强了对中心型细胞的抑制作用，荷包牡丹碱则阻断了这种抑制作用；而甘氨酸增强了对偏心型细胞的抑制作用，士的宁则阻断了这种抑制作用，无论这些细胞是“持续型”还是“瞬变型”。文中讨论了以下可能性：(A)天冬氨酸可能是“on-”和“off-持续型”细胞的兴奋性递质，而乙酰胆碱可能是“on-”和“off-瞬变型”细胞的兴奋性递质；(B)γ-氨基丁酸可能是对中心型细胞的抑制性递质，而甘氨酸可能是对偏心型细胞的抑制性递质。
